Apellis Pharmaceuticals (APLS) #IPO Preview

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Company: Apellis Pharmaceuticals
Symbol: APLS
Description: They are a clinical-stage biopharmaceutical company focused on the discovery and development of novel therapeutic compounds for autoimmune and inflammatory diseases.
Shares: 10.7 million
Price Range: $13.00-$15.00
Trade Date: 11/9
Underwriter(s): Citigroup, J.P. Morgan, Evercore ISI
Filed 10-20-17

Link to S-1/A Prospectus

Link to Retail Roadshow

Business: They have the most advanced clinical program targeting C3. They believe that their lead product candidate, APL-2, has the potential to be a best-in-class treatment that may address the limitations of existing treatment options or provide a treatment option where there currently is none. APL-2 has already shown activity that they believe is clinically meaningful in clinical trials for two distinct medical conditions—geographic atrophy in age-related macular degeneration, or GA, and paroxysmal nocturnal hemoglobinuria, or PNH—and they plan to conduct clinical trials in additional complement-dependent diseases. In their ongoing Phase 2 trial of APL-2 in patients with GA, treatment with APL-2 resulted in a significant reduction in the rate of GA lesion growth over 12 months, and in their two ongoing Phase 1b trials in PNH, APL-2 achieved improvements in transfusion dependency, hemoglobin levels and other hematological indicators that they believe are clinically meaningful. They are also developing other novel compounds targeting C3. They hold worldwide commercialization rights to APL-2 and these other novel compounds targeting C3.

ApellisDrugs

Insider Buying: Certain of their existing shareholders, including certain of their directors and affiliates of their directors, and their affiliated entities have indicated an interest in purchasing an aggregate of up to approximately $70.0 million of their common shares in this offering at the initial public offering price per share.

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Apellis Pharmaceuticals (APLS) #IPO Preview
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