{"id":3012,"date":"2017-09-21T15:58:34","date_gmt":"2017-09-21T19:58:34","guid":{"rendered":"http:\/\/www.ipoboutique.com\/blog\/?p=3012"},"modified":"2017-09-21T15:58:34","modified_gmt":"2017-09-21T19:58:34","slug":"nightstar-therapeutics-limited-nite-ipo-preview","status":"publish","type":"post","link":"https:\/\/www.ipoboutique.com\/blog\/nightstar-therapeutics-limited-nite-ipo-preview\/","title":{"rendered":"Nightstar Therapeutics Limited (NITE) IPO Preview"},"content":{"rendered":"

\"\"<\/a><\/p>\n

Company: Nightstar Therapeutics Limited<\/strong>
\nSymbol: NITE
\nDescription: They are a leading clinical-stage gene therapy company focused on developing and commercializing novel one-time treatments for patients suffering from rare inherited retinal diseases that would otherwise progress to blindness.
\nShares: 5.36 million ADSs
\nRange: $13.00-$15.00
\nTrade Date: 9\/28
\nUnderwriter(s): Jefferies, Leerink Partners, BMO Capital Markets
\nCo-Manager(s): Wedbush PacGrow, Chardan<\/p>\n

Link to S-1\/A Prospectus<\/a><\/strong><\/p>\n

Link to Retail Roadshow<\/a><\/strong><\/p>\n

Business<\/strong>: Leveraging their\u00a0expertise in ophthalmology, gene therapy and drug development, they are developing a pipeline of proprietary product candidates that are designed to substantially modify or halt the progression of inherited retinal diseases for which there are no currently approved treatments. Their\u00a0lead product candidate, NSR-REP1, for the treatment of choroideremia, or CHM, is entering Phase 3 clinical development in the first half of 2018 and represents the most clinically advanced product candidate for this indication worldwide. In data from 32 patients treated with NSR-REP1 across four open-label clinical trials, over 90% of treated patients maintained their visual acuity over a one-year follow-up period. In some cases, they\u00a0also observed substantial improvements in visual acuity. They are also conducting a Phase 1\/2 clinical trial with theirsecond product candidate, NSR-RPGR, for the treatment of X-linked retinitis pigmentosa, or XLRP. Their\u00a0third product candidate, NSR-BEST1, is in preclinical development for the treatment of Best vitelliform macular dystrophy, or Best disease.<\/p>\n

\"NightstarTherapetuicsDrugs\"<\/a><\/p>\n

Competition and Sector Performance: \u00a0Healthcare Related IPOs as of 9.21.17pm<\/strong><\/p>\n

\"HealthCareIPOs09212017\"<\/a><\/p>\n

Insider Buying:\u00a0<\/strong>Certain of their\u00a0existing stockholders have indicated an interest in purchasing up to an aggregate of approximately $25 million of shares of their\u00a0common stock.<\/p>\n

Collaborations & License Agreement:\u00a0<\/strong><\/p>\n

Oxford University Innovation Limited –\u00a0<\/i>In November 2013, they\u00a0entered into a license agreement with Oxford. Under the 2013 Oxford Agreement, they acquired an exclusive worldwide license, with the right to grant sublicenses, to develop, research, make, import, use, sell, lease, license or otherwise commercially exploit products, including NSR-REP1, covered by the patents and know-how relating to vectors for use in gene therapy for CHM licensed under the 2013 Oxford Agreement for any and all uses.<\/p>\n

 <\/p>\n

Additionally, in November 2015, they entered into five separate license agreements with Oxford, under which they acquired exclusive worldwide licenses, with the right to grant sublicenses, to develop, research, make, import, use, sell, lease, license or otherwise commercially exploit products, including NSR-RPGR, NSR-BEST1 and three other preclinical gene therapy product candidates, covered by the licensed patents and know-how relating to gene therapy for any and all uses.<\/p>\n

Oxford BioMedica (UK) Limited —\u00a0<\/i>In December 2013, they entered into a license agreement with Oxford BioMedica (UK) Limited, or BioMedica. Under the BioMedica Agreement, they acquired a non-exclusive license in the United States to manufacture, use, supply, sell, offer to sell, store, develop, research and import certain AAV products for the treatment of CHM, with the right to grant sublicenses to development partners.<\/p>\n

Book-Building Status<\/strong>: The way the book comes together during the week of the roadshow is the most critical indicator to first-day and first-week performance. IPO Boutique uses its 45 years of experience and sources all over the street to gather daily subscription levels, specific price guidance and what type of investors are currently in the book or are anchoring orders in the book. In addition, recent underwriter performance on sector specific deals is a strong factor that IPO Boutique takes into account when determining if our clients should indicate for any offering.<\/p>\n

IPO Boutique subscription clients receive daily updates on this critical information.<\/a><\/p>\n

Conclusion<\/strong>: IPO Boutique provides ratings, daily commentary and a forecast for how this IPO will open vs. its offering price. We have kept a\u00a0track record<\/a>\u00a0with our performance for last 12 years at our website.<\/p>\n

Indicate with confidence,\u00a0SUBSCRIBE<\/a>\u00a0today.<\/p>\n","protected":false},"excerpt":{"rendered":"

Company: Nightstar Therapeutics Limited Symbol: NITE Description: They are a leading clinical-stage gene therapy company focused on developing and commercializing novel one-time treatments for patients suffering from rare inherited retinal diseases that would otherwise progress to blindness. Shares: 5.36 million ADSs Range: $13.00-$15.00 Trade Date: 9\/28 Underwriter(s): Jefferies, Leerink Partners, BMO Capital Markets Co-Manager(s): Wedbush[…]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"zakra_general_container_width":0,"zakra_general_content_width":0,"zakra_general_sidebar_width":0,"zakra_sticky_header":"customizer","zakra_header_main_area":true,"zakra_site_logo_width":0,"zakra_header_top_enabled":"customizer","zakra_header_top_style":"customizer","zakra_primary_menu_item_style":"customizer","zakra_page_header_text_color":"","zakra_page_header_layout":"customizer","zakra_page_title_bg":"","zakra_footer_widgets_bg_image":0,"zakra_page_title_bg_repeat":"customizer","zakra_page_title_bg_position":"customizer","zakra_page_title_bg_size":"customizer","zakra_page_title_bg_attachment":"customizer","zakra_breadcrumbs_enabled":"customizer","zakra_breadcrumbs_text_color":"","zakra_breadcrumbs_separator_color":"","zakra_breadcrumbs_link_color":"","zakra_breadcrumbs_link_hover_color":"","zakra_page_title_bg_image":0,"zakra_footer_widgets_enabled":"customizer","zakra_footer_column_layout_1_style":"customizer","zakra_footer_widgets_bg":"","zakra_footer_widgets_bg_repeat":"customizer","zakra_footer_widgets_bg_position":"customizer","zakra_footer_widgets_bg_size":"customizer","zakra_footer_widgets_bg_attachment":"customizer","zakra_footer_bar_enabled":"customizer","zakra_footer_bar_style":"customizer","footnotes":""},"categories":[24],"tags":[1347],"class_list":["post-3012","post","type-post","status-publish","format-standard","hentry","category-ipo","tag-nite"],"_links":{"self":[{"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/posts\/3012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/comments?post=3012"}],"version-history":[{"count":1,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/posts\/3012\/revisions"}],"predecessor-version":[{"id":3015,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/posts\/3012\/revisions\/3015"}],"wp:attachment":[{"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/media?parent=3012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/categories?post=3012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ipoboutique.com\/blog\/wp-json\/wp\/v2\/tags?post=3012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}